Leslie Coffee

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Jul 9

stormflies:

i’ll swim and sail on savage seas with ne’er a fear of drowning
and gladly ride the waves of life if you will marry me

Jul 9

8bitfuture:

Video: The Fujitsu lettuce factory.

After several years of shutting down production lines in chip fabrication facilities, the Japanese electronics giant is turning its sterile, dust free factory into a hydroponic lettuce farm.

edit: Have updated the video to a working link, it’s in Japanese now but you can still catch an English version here.

sellykitann:

cumberbabegonehiddlestoned:

styleofdress:

because i hate it when people post these without recipes, here are all of them. some of these aren’t EXACTLY the same, but they’re close enough to still be delicious.

triple layer brownie cake / cherry bliss brownie / chocolate truffle layer cake / snickers peanut butter brownie ice cream cake / surprise inside ice cream balls / chocolate filled cream puffs / brownie cookies / chocolate snickers cake / chocolate lasagna / double chocolate brownies

THERE ARE CHILDREN HERS

YOU ARE A BEAUTIFUL PERSON YOU.

(Source: shams94)

frlcker:

do u ever forget to sleep or eat or drink water or something and ur like “oh shit yeah I need that to live”

(Source: studip)

Uri Alon: How theater inspires mentoring in science

(Source: weheartit.com)

May 2

happyvibes-healthylives:

Vegetarian Indian Dishes

May 1
ucsdhealthsciences:

Prostate Cancer and Blood Lipids Share Genetic LinksBased on analyses of genome-wide association studies using novel analytical methods
Numerous studies have suggested a relationship between cardiovascular disease risk factors and prostate cancer. A new study by researchers at the University of California, San Diego School of Medicine, with colleagues in Norway, significantly refines the association, highlighting genetic risk factors associated with low density lipoprotein (LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of these blood lipids and to prostate cancer.
The findings, published in the April 30, 2014 online issue of the International Journal of Epidemiology, provide new insights into the pathobiology of prostate cancer and may point to novel therapies to lower blood lipid levels that might help prevent prostate cancer – the second most common cause of cancer death among American men.
The research team, headed by senior authors Anders M. Dale, PhD, professor in the departments of radiology, neurosciences and psychiatry at the UC San Diego School of Medicine, and Ole Andreassen, professor of psychiatry at Oslo University, applied a genetic epidemiology method to assess statistics from multiple genome-wide association studies, looking for genetic overlap between the phenotypes for prostate cancer and cardiovascular disease (CVD) risk factors. In the case of the latter, they specifically investigated triglycerides, LDL and high density lipoprotein cholesterol, systolic blood pressure, body mass index, waist-hip ratio and type 2 diabetes.
The researchers also examined enrichment of single nucleotide polymorphisms – bits of DNA that vary among individuals – associated with prostate cancer and CVD risk.
LDL cholesterol and triglycerides displayed a strong association with prostate cancer.
“It’s fair to say that risk relationships of various sorts have been proposed between prostate cancer and cardiovascular disease, although not comorbidity per se,” said co-author Ian G. Mills, PhD, of the University of Oslo and Oslo University Hospital in Norway. “There is a lack of consistency across cohorts, however, in size and direction of effects, depending on cardiovascular risk factor considered. The significant risk association with LDL cholesterol and triglycerides versus the other traits at a genetic level was novel and unexpected.”
Mills said the identification of 17 pleiotropic loci – specific sites in the genome which may affect the expression of a number of genes and influence a range of biological pathways, in this case affecting both prostate cancer and cardiovascular disease risk – was a key finding. He said the loci provide clues to the common regulatory elements that affect expression of disease-related genes. They may be incorporated into future disease risk test panels. And they might, ultimately, help shape “genetically stratified dietary or chemoprevention studies repurposing clinically approved drugs that regulate blood lipid levels” to alter the risk of developing prostate cancer, he said.
The current findings were made possible through use of a novel analytical approach developed by researchers at UC San Diego and University of Oslo, which previously had been shown to increase the statistical power for gene discovery in other diseases, including hypertension, neurological diseases, psychiatric disorders and immune-mediated diseases.
Pictured above: Micrograph of normal prostatic glands and those with prostate adenocarcinoma (upper right portion of image). Wiki-Commons.

ucsdhealthsciences:

Prostate Cancer and Blood Lipids Share Genetic Links
Based on analyses of genome-wide association studies using novel analytical methods

Numerous studies have suggested a relationship between cardiovascular disease risk factors and prostate cancer. A new study by researchers at the University of California, San Diego School of Medicine, with colleagues in Norway, significantly refines the association, highlighting genetic risk factors associated with low density lipoprotein (LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of these blood lipids and to prostate cancer.

The findings, published in the April 30, 2014 online issue of the International Journal of Epidemiology, provide new insights into the pathobiology of prostate cancer and may point to novel therapies to lower blood lipid levels that might help prevent prostate cancer – the second most common cause of cancer death among American men.

The research team, headed by senior authors Anders M. Dale, PhD, professor in the departments of radiology, neurosciences and psychiatry at the UC San Diego School of Medicine, and Ole Andreassen, professor of psychiatry at Oslo University, applied a genetic epidemiology method to assess statistics from multiple genome-wide association studies, looking for genetic overlap between the phenotypes for prostate cancer and cardiovascular disease (CVD) risk factors. In the case of the latter, they specifically investigated triglycerides, LDL and high density lipoprotein cholesterol, systolic blood pressure, body mass index, waist-hip ratio and type 2 diabetes.

The researchers also examined enrichment of single nucleotide polymorphisms – bits of DNA that vary among individuals – associated with prostate cancer and CVD risk.

LDL cholesterol and triglycerides displayed a strong association with prostate cancer.

“It’s fair to say that risk relationships of various sorts have been proposed between prostate cancer and cardiovascular disease, although not comorbidity per se,” said co-author Ian G. Mills, PhD, of the University of Oslo and Oslo University Hospital in Norway. “There is a lack of consistency across cohorts, however, in size and direction of effects, depending on cardiovascular risk factor considered. The significant risk association with LDL cholesterol and triglycerides versus the other traits at a genetic level was novel and unexpected.”

Mills said the identification of 17 pleiotropic loci – specific sites in the genome which may affect the expression of a number of genes and influence a range of biological pathways, in this case affecting both prostate cancer and cardiovascular disease risk – was a key finding. He said the loci provide clues to the common regulatory elements that affect expression of disease-related genes. They may be incorporated into future disease risk test panels. And they might, ultimately, help shape “genetically stratified dietary or chemoprevention studies repurposing clinically approved drugs that regulate blood lipid levels” to alter the risk of developing prostate cancer, he said.

The current findings were made possible through use of a novel analytical approach developed by researchers at UC San Diego and University of Oslo, which previously had been shown to increase the statistical power for gene discovery in other diseases, including hypertension, neurological diseases, psychiatric disorders and immune-mediated diseases.

Pictured above: Micrograph of normal prostatic glands and those with prostate adenocarcinoma (upper right portion of image). Wiki-Commons.

May 1

ricktimus:

Neil deGrasse Tyson is not impressed with all your sexism.

So there were actually 3 key women at this time in astrophysics, all of which found themselves at Harvard in the early-mid 1900s and 2 of which found themselves ‘hired’ (either as unpaid volunteers or for a fraction of the male wage) as Edward Pickering’s ‘Female Computers’ charged with tedious cataloging of astronomical photographic plates and the resulting calculations. 

They were:

Annie Jump Cannon - she designed the astronimical classification system we still use today

Henrietta Leavitt - she discovered the luminosity law that we still use to measure the size of the cosmos.

Cecilia Payne - was the first one to work out that the sun is made of primarily helium and hydrogen. She studied for a phD at Cambridge but wasn’t awarded one because she was a woman. She moved to Radcliff college (the Harvard subsection for the instruction of women) and got her phD there in 1925 and even though she spent her career there, she wasn’t given the title of Professor until 1954. 

See these links for reference: 

http://siarchives.si.edu/blog/pickering-women

http://www.thewire.com/culture/2014/04/this-episode-of-neil-degrasse-tysons-cosmos-was-for-the-ladies/361297/

Oh also - get this: “As Bill Bryson notes in his book, A Short History of Nearly Everything: “(Just to put these insights into perspective, it is perhaps worth noting that at the time Leavitt and Cannon were inferring fundamental properties of the cosmos from dim smudges on photographic plates, the Harvard astronomer William H. Pickering*, who could of course peer into a first-class telescope as often as he wanted, was developing his seminal theory that dark patches on the Moon were caused by swarms of seasonally migrating insects.)”“

womenrockscience:

Meet Mary Sherman Morgan, rocket scientist, munitions and chemical engineer and one of the most instrumental players in the launch of America’s first satellite, Explorer I (shown above). According to her colleagues she “single-handedly saved America’s space programme”.
Mary started out life as a poor farm girl in North Dakota, her parents chose not to educate her by choice so that she could work on the farm. Eventually, she managed to graduate high school and then ran away from home to go to college and study chemical engineering.
During her studies, WWII broke out and there was a shortage of chemists in the country. Mary was offered a “Top Secret” job at a factory and had to accept without being told what the factory made or what her job would be. It turned out it was a munitions factory – Mary was put in charge of the manufacture of 3 different types of explosive. In her tenure the factory produced over 1 billion pounds of ordnance for WWII.
With the war behind her and after graduating her degree she started working for Rocketdyne under Dr Silverman. In the 1950’s the US was in a race to launch its first satellite into space. American rockets were just not successful, they either couldn’t accelerate to the necessary speed or would blow up on the launch pad. Out of dozens of other engineers Dr Silverman put Mary in charge of solving this problem. She invented Hydyne, a brand new and powerful liquid fuel. In 1958 Explorer I was successfully launched into space using Jupiter-C rockets powered by Hydyne fuel.
Shortly after this success, Mary left the world of work to become a stay at home mum. Much of her work was top secret and she was a very private person - she actively avoided the press. Barely anyone knew about what she did for the space programme.  It was only at her funeral did her colleagues begin to share her story. “Mary single-handedly saved America’s space programme” he said “and nobody knows but a handful of old men”
Sources: Sherman-Morgan, BBC

womenrockscience:

Meet Mary Sherman Morgan, rocket scientist, munitions and chemical engineer and one of the most instrumental players in the launch of America’s first satellite, Explorer I (shown above). According to her colleagues she “single-handedly saved America’s space programme”.

Mary started out life as a poor farm girl in North Dakota, her parents chose not to educate her by choice so that she could work on the farm. Eventually, she managed to graduate high school and then ran away from home to go to college and study chemical engineering.

During her studies, WWII broke out and there was a shortage of chemists in the country. Mary was offered a “Top Secret” job at a factory and had to accept without being told what the factory made or what her job would be. It turned out it was a munitions factory – Mary was put in charge of the manufacture of 3 different types of explosive. In her tenure the factory produced over 1 billion pounds of ordnance for WWII.

With the war behind her and after graduating her degree she started working for Rocketdyne under Dr Silverman. In the 1950’s the US was in a race to launch its first satellite into space. American rockets were just not successful, they either couldn’t accelerate to the necessary speed or would blow up on the launch pad. Out of dozens of other engineers Dr Silverman put Mary in charge of solving this problem. She invented Hydyne, a brand new and powerful liquid fuel. In 1958 Explorer I was successfully launched into space using Jupiter-C rockets powered by Hydyne fuel.

Shortly after this success, Mary left the world of work to become a stay at home mum. Much of her work was top secret and she was a very private person - she actively avoided the press. Barely anyone knew about what she did for the space programme.  It was only at her funeral did her colleagues begin to share her story. “Mary single-handedly saved America’s space programme” he said “and nobody knows but a handful of old men”

Sources: Sherman-Morgan, BBC